Article
PDGF-B gene single-nucleotide polymorphisms are not predictive for disease onset or progression of IgA nephropathy.
Clinical nephrology - 1 Feb 2007
Bicanski B, Wenderdel M, Mertens Peter R, Senderek J, Panzer U, Steinmetz O, Stahl R A K, Cerullo G, Diletta Torres D, Schena F P, Zerres K, Floege J
Abstract excerpt
BACKGROUND: Few genetic factors have been identified that determine susceptibility to and progression of IgA-nephropathy (IgAN). Given that IgAN is usually characterized by mesangioproliferative glomerulonephritis and that PDGF-B is of central pathophysiological relevance in this process, we analyzed four single-nucleotide polymorphisms (SNPs) of the PDGF-B gene to evaluate a possible association of these SNPs...
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