Article
Inhibitors of vacuolar ATPase proton pumps inhibit human prostate cancer cell invasion and prostate-specific antigen expression and secretion.
International journal of cancer - 15 Jan 2013
Michel Vera, Licon-Munoz Yamhilette, Trujillo Kristina, Bisoffi Marco, Parra Karlett J
Abstract excerpt
Vacuolar ATPases (V-ATPases) comprise specialized and ubiquitously distributed pumps that acidify intracellular compartments and energize membranes. To gain new insights into the roles of V-ATPases in prostate cancer (PCa), we studied the effects of inhibiting V-ATPase pumps in androgen-dependent...
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