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Article

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three.

Biochimica et biophysica acta - 1 Oct 2007

Melin Patricia, Hosy Eric, Vivaudou Michel, Becq Frédéric

Abstract excerpt

The sulfonylurea glibenclamide is widely used as an open-channel blocker of the CFTR chloride channel. Here, we used site-directed mutagenesis to identify glibenclamide site of interaction: a positively charged residue K978, located in the cytoplasmic loop 3. Charge-neutralizing mutations K978A, K978Q, K978S abolished the inhibition of forskolin-activated CFTR chloride current by glibenclamide but not by...

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Source

Identifiers

PMID: 17582383
DOI: 10.1016/j.bbamem.2007.05.013

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three.PMID 17582383Read ↗

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