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Article

Is hEXO1 a Cancer Predisposing Gene?

1 Aug 2004

Abstract excerpt

Changes in the efficiency of DNA repair and recombination activities can cause predisposition to cancer. The finding that hereditary nonpolyposis colorectal cancer (HNPCC) families frequently harbor mutations in DNA mismatch repair (MMR) genes has generated widespread interest in this research area (1-5). At the time of writing, germ line mutations in at least four genes, hMSH2, hMSH6, hMLH1, and hPMS2, all...

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PMID: 15328369
DOI: 10.1158/1541-7786.427.2.8

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