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Article

Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity.

Science (New York, N.Y.) - 30 Jan 2004

Xie Lili, Miller Leah M, Chatterjee Champak, Averin Olga, Kelleher Neil L, van der Donk Wilfred A

Abstract excerpt

The lantibiotic lacticin 481 is synthesized on ribosomes as a prepeptide (LctA) and posttranslationally modified to its mature form. These modifications include dehydration of serines and threonines, followed by intramolecular addition of cysteines to the unsaturated amino acids, which generates cyclic thioethers. This process breaks eight chemical bonds and forms six newbonds and is catalyzed by one enzyme,...

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Identifiers

PMID: 14752162
DOI: 10.1126/science.1092600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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