Article
Maturation by LctT is required for biosynthesis of full-length lantibiotic lacticin 481.
Applied and environmental microbiology - 1 Jan 2005
Uguen Patricia, Hindré Thomas, Didelot Sandrine, Marty Christel, Haras Dominique, Le Pennec Jean-Paul, Vallée-Réhel Karine, Dufour Alain
Abstract excerpt
In lantibiotic lacticin 481 biosynthesis, LctT cleaves the precursor peptide and exports mature lantibiotic. Matrix-assisted laser desorption ionization-time of flight mass spectrometry revealed that a truncated form of lacticin 481 is produced in the absence of LctT or after cleavage site inactivation. Production of truncated lacticin 481 is 4-fold less efficient, and its specific activity is about 10-fold lower.
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