Article
Relatedness between the two-component lantibiotics lacticin 3147 and staphylococcin C55 based on structure, genetics and biological activity.
BMC microbiology - 2 Apr 2007
O'Connor Eileen B, Cotter Paul D, O'Connor Paula, O'Sullivan Orla, Tagg John R, Ross R Paul, Hill Colin
Abstract excerpt
BACKGROUND: Two component lantibiotics, such as the plasmid-encoded lacticin 3147 produced by Lactococcus lactis DPC3147 and staphylococcin C55 produced by Staphylococcus aureus C55, represent an emerging subgroup of bacteriocins. These two bacteriocins are particularly closely related, exhibiting 86% (LtnA1 and C55alpha) and 55% (LtnA2 and C55beta) identity in their component peptides. The aim of this study was...
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