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Article

Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression.

Blood - 15 May 2004

Zhang Ying, Nagata Yuka, Yu Guangyao, Nguyen Hao G, Jones Matthew R, Toselli Paul, Jackson Carl W, Tatsuka Masaaki, Todokoro Kazuo, Ravid Katya

Abstract excerpt

Megakaryocytes skip late anaphase and cytokinesis during endomitosis. We found normal expression and localization of a fundamental regulator of mitosis, Aurora-B/AIM-1, during prophase in polyploidizing mouse bone marrow megakaryocytes. At late anaphase, however, Aurora-B/AIM-1 is absent or mislocalized. Megakaryocytes treated with a proteasome inhibitor display Aurora-B/AIM-1 properly expressed and localized to...

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Identifiers

PMID: 14751927
DOI: 10.1182/blood-2003-09-3365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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