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Article

Heterogeneous glioblastoma cell cross-talk promotes phenotype alterations and enhanced drug resistance.

Oncotarget - 1 Dec 2015

Motaln Helena, Koren Ana, Gruden Kristina, Ramšak Živa, Schichor Christian, Lah Tamara T

Abstract excerpt

Glioblastoma multiforme is the most lethal of brain cancer, and it comprises a heterogeneous mixture of functionally distinct cancer cells that affect tumor progression. We examined the U87, U251, and U373 malignant cell lines as in vitro models to determine the impact of cellular cross-talk on their phenotypic alterations in co-cultures. These cells were also studied at the transcriptome level, to define the...

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Identifiers

PMID: 26517510
DOI: 10.18632/oncotarget.5701
PMCID: PMC4747385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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