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Article

Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN.

Cancer cell - 1 Jan 2004

Sumitomo Makoto, Iwase Akira, Zheng Rong, Navarro Daniel, Kaminetzky David, Shen Ruoqian, Georgescu Maria-Magdalena, Nanus David M

Abstract excerpt

We show in this study that endogenous NEP and PTEN associate in cells directly through electrostatic interactions between a highly basic residue stretch in the intracellular domain of NEP and the major phosphorylation site in PTEN's tail. NEP binds and engages in higher order complexes both phosp...

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Source

Identifiers

PMID: 14749127
DOI: 10.1016/s1535-6108(03)00331-3

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14749127-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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