Article
Neisseria gonorrhoeae PilC expression provides a selective mechanism for structural diversity of pili.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992
Jonsson A B, Pfeifer J, Normark S
Abstract excerpt
Pili of Neisseria gonorrhoeae undergo both phase and structural variation. Phase variation of gonococcal pili can be caused by a RecA-independent on/off switch in PilC, a protein involved in pilus biogenesis. We show here that spontaneous nonpiliated PilC- derivatives as well as PilC- insertional mutants have also acquired sequence alterations in pilE relative to the pilE gene of the piliated MS11mk(P+)-u parent,...
Topics
- Amino Acid Sequence
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Base Sequence
- Blotting, Southern
- DNA, Bacterial
- Fimbriae Proteins
- Fimbriae, Bacterial
- Genes, Bacterial
- Genetic Variation