Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assembly.

Abstract excerpt

Pili prepared from Neisseria gonorrhoeae contain minor amounts of a 110 kd outer membrane protein denoted PilC. The corresponding gene exists in two copies, pilC1 and pilC2, in most strains of N.gonorrhoeae. In the piliated strain MS11(P+), only one of the genes, pilC2, was expressed. Inactivation of pilC2 by a mTnCm insertion resulted in a nonpiliated phenotype, while a mTnCm insertion in pilC1 had no effect on...

Topics

• Amino Acid Sequence
• Bacterial Outer Membrane Proteins
• Base Sequence
• Cloning, Molecular
• Fimbriae Proteins
• Fimbriae, Bacterial
• Frameshift Mutation
• Genes, Bacterial
• Genetic Variation
• Molecular Sequence Data
• Molecular Weight