Telomere Shortening Alters the Kinetics of the DNA Damage Response after Ionizing Radiation in Human Cells

Abstract excerpt

Studies of telomerase-deficient mice and human cell lines have showed that telomere shortening enhances sensitivity to ionizing radiation (IR). The molecular basis for this observation remains unclear. To better understand the connection between telomere shortening and radiation sensitivity, we evaluated components of the DNA damage response pathway in normal human fibroblasts with short and long telomeres....

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