Article
St John's wort and imipramine-induced gene expression profiles identify cellular functions relevant to antidepressant action and novel pharmacogenetic candidates for the phenotype of antidepressant treatment response.
Molecular psychiatry - 1 Mar 2004
Wong M-L, O'Kirwan F, Hannestad J P, Irizarry K J L, Elashoff D, Licinio J
Abstract excerpt
Both the prototypic tricyclic antidepressant imipramine (IMI) and the herbal product St John's wort (SJW) can be effective in the treatment of major depressive disorder. We studied hypothalamic gene expression in rats treated with SJW or IMI to test the hypothesis that chronic antidepressant trea...
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