Article
Mutations linked to drug resistance, human immunodeficiency virus type 1 biologic phenotype and their association with disease progression in children receiving nucleoside reverse transcriptase inhibitors.
The Pediatric infectious disease journal - 1 Jan 2004
Englund Janet A, Raskino Claire, Vavro Cindy, Palumbo Paul, Ross Lisa L, McKinney Ross, Nikolic-Djokic Divna, Colgrove Robert C, Baker Carol J
Abstract excerpt
BACKGROUND: Few data are available concerning the impact of antiretroviral resistance in response to antiviral therapy in children. We evaluated the development of antiretroviral genotypic resistance and clinical outcome in a subgroup of children involved in a prospective antiretroviral therapy trial (Pediatric AIDS Clinical Trials Group Protocol 152). DESIGN: We studied 26 matched case/control pairs. A case was...
Topics
- CD4 Lymphocyte Count
- Case-Control Studies
- Child
- Child, Preschool
- Didanosine
- Drug Resistance, Viral
- Female
- HIV Infections
- HIV-1
- Humans