Article
Drug resistance and virologic response in NUCA 3001, a randomized trial of lamivudine (3TC) versus zidovudine (ZDV) versus ZDV plus 3TC in previously untreated patients.
AIDS (London, England) - 1 Aug 1996
Kuritzkes D R, Quinn J B, Benoit S L, Shugarts D L, Griffin A, Bakhtiari M, Poticha D, Eron J J, Fallon M A, Rubin M
Abstract excerpt
OBJECTIVE: To study the effect of HIV-1 resistance to lamivudine (3TC) and zidovudine (ZDV), and syncytium-inducing (SI) phenotype on virologic response to treatment with ZDV, 3TC, or ZDV plus 3TC in previously untreated individuals with HIV-1 infection. DESIGN: A prospective virologic substudy o...
Topics
- Adult
- Anti-HIV Agents
- Double-Blind Method
- Drug Resistance
- Drug Therapy, Combination
- Female
- Genes, Viral
- HIV Infections
- HIV-1
- Humans
- Lamivudine
- Male
- Mutation
- Virus Replication
- Zidovudine