Prevalence and effect of pre-treatment drug resistance on the virological response to antiretroviral treatment initiated in HIV-infected children - a EuroCoord-CHAIN-EPPICC joint project.

doi:10.1186/s12879-016-1968-2

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Article

Prevalence and effect of pre-treatment drug resistance on the virological response to antiretroviral treatment initiated in HIV-infected children - a EuroCoord-CHAIN-EPPICC joint project.

BMC infectious diseases - 8 Nov 2016

Ngo-Giang-Huong Nicole, Wittkop Linda, Judd Ali, Reiss Peter, Goetghebuer Tessa, Duiculescu Dan, Noguera-Julian Antoni, Marczynska Magdalena, Giacquinto Carlo, Ene Luminita, Ramos Jose T, Cellerai Cristina, Klimkait Thomas, Brichard Benedicte, Valerius Niels, Sabin Caroline, Teira Ramon, Obel Niels, Stephan Christoph, de Wit Stéphane, Thorne Claire, Gibb Diana, Schwimmer Christine, Campbell Maria Athena, Pillay Deenan, Lallemant Marc

Abstract excerpt

BACKGROUND: Few studies have evaluated the impact of pre-treatment drug resistance (PDR) on response to combination antiretroviral treatment (cART) in children. The objective of this joint EuroCoord-CHAIN-EPPICC/PENTA project was to assess the prevalence of PDR mutations and their association with virological outcome in the first year of cART in children. METHODS: HIV-infected children <18 years initiating cART...

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PMID: 27825316
DOI: 10.1186/s12879-016-1968-2
PMCID: PMC5101717

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