Article
Role of granulocyte/macrophage colony-stimulating factor in zymocel-induced hepatic granuloma formation.
The American journal of pathology - 1 Jan 2001
Wynn A A, Miyakawa K, Miyata E, Dranoff G, Takeya M, Takahashi K
Abstract excerpt
To examine the role of granulocyte/macrophage colony-stimulating factor (GM-CSF) in inflammatory granuloma formation, we injected GM-CSF-deficient (GM-CSF(-/-)) mice and wild-type (GM-CSF(+/+)) mice intravenously with 2 mg of zymocel, and mice were killed at various intervals for examination. In GM-CSF(-/-) mice, we demonstrated a marked delay of zymocel-induced hepatic granuloma formation until 5 days after...
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