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Article

Biochemical characterization of the topoisomerase domain of Methanopyrus kandleri topoisomerase V.

The Journal of biological chemistry - 17 Oct 2014

Rajan Rakhi, Osterman Amy K, Gast Alexandra T, Mondragón Alfonso

Abstract excerpt

Topoisomerases are ubiquitous enzymes that modify the topological state of DNA inside the cell and are essential for several cellular processes. Topoisomerase V is the sole member of the type IC topoisomerase subtype. The topoisomerase domain has a unique fold among topoisomerases, and the putative active site residues show a distinct arrangement. The present study was aimed at identifying the roles of the...

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Identifiers

PMID: 25135643
DOI: 10.1074/jbc.M114.590711
PMCID: PMC4200249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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