Article
SAR studies of dihydro-beta-agarofuran sesquiterpenes as inhibitors of the multidrug-resistance phenotype in a Leishmania tropica line overexpressing a P-glycoprotein-like transporter.
Journal of medicinal chemistry - 29 Jan 2004
Cortés-Selva Fernando, Campillo Mercedes, Reyes Carolina P, Jiménez Ignacio A, Castanys Santiago, Bazzocchi Isabel L, Pardo Leonardo, Gamarro Francisco, Ravelo Angel G
Abstract excerpt
A series of dihydro-beta-agarofuran sesquiterpenes isolated from the leaves of Maytenus cuzcoina (1-10) or semisynthetic derivatives (11-30) have been tested on a multidrug-resistant Leishmania tropica line overexpressing a P-glycoprotein-like transporter to determine their ability to revert the...
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