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Article

In silico screening of antifolate based novel inhibitors from Brucea mollis Wall. ex kurz against quadruple mutant drug resistant PfDHFR.

Combinatorial chemistry & high throughput screening - 1 Jan 2014

Borkakoty Biswajyoti, Sarma Kishore, Parida Pratap, Prakash Anil, Mohapatra Pradyumna Kishore, Mahanta Jagadish

Abstract excerpt

Plasmodium falciparum is the most lethal form of the genus Plasmodium which causes malaria, a 'disease of antiquity'. Globally it affects the health and socio-economic development of a large population especially in Sub-Saharan Africa and Southeast Asia. The Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) is an important target of antimalarial drugs. Mutations at the active site of...

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Source

Identifiers

PMID: 25053170
DOI: 10.2174/1386207317666140521153305

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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