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Article

Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma.

International journal of cancer - 1 Mar 2004

Hoang Bang H, Kubo Tadahiko, Healey John H, Sowers Rebecca, Mazza BethAnne, Yang Rui, Huvos Andrew G, Meyers Paul A, Gorlick Richard

Abstract excerpt

The Wingless-type (Wnt) family of proteins and its coreceptor LRP5 have recently been implicated in human skeletal development. Wnt pathway modulates cell fate and cell proliferation during embryonic development and carcinogenesis through activation of receptor-mediated signaling. Osteosarcoma (OS) is a bone-forming tumor of mesenchymal origin whose growth control has been linked to autocrine or paracrine...

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Source

Identifiers

PMID: 14735475
DOI: 10.1002/ijc.11677

Genes

LRP5
FZD1
WNT1
WNT11
WNT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma.PMID 14735475Read ↗

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