Article
c-Kit expression and mutations in phyllodes tumors of the breast.
Anticancer research - 1 Nov 2010
Bose Prithviraj, Dunn S Terence, Yang Jian, Allen Richard, El-Khoury Christian, Tfayli Arafat
Abstract excerpt
BACKGROUND: Phyllodes tumors (PTs) represent uncommon fibroepithelial lesions of the breast that express c-Kit and platelet-derived growth factor receptor-alpha, similar to gastrointestinal stromal tumors (GISTs). 'Activating' mutations in these genes underlie responsiveness of GISTs to imatinib. Standard treatment for breast PTs is wide local excision, with no role for targeted therapies. PATIENTS AND METHODS:...
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