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Article

Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms

5 Feb 2003

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Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Eosinophilic Disorders and Syndromes
Share to Mast cells and histamine

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12569358
DOI: 10.1038/sj.onc.1206120

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasmsPMID 12569358Read ↗

Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kitSemantic proximity Read ↗

c-Kit Receptors as a Therapeutic Target in Cancer: Current InsightsSemantic proximity Read ↗

Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms.Semantic proximity Read ↗

[Therapeutically relevant mutations in the receptor tyrosine kinase KIT in mastocytosis].Semantic proximity Read ↗

Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies.Semantic proximity Read ↗

Constitutive activation of c-kit by the juxtamembrane but not the catalytic domain mutations is inhibited selectively by tyrosine kinase inhibitors STI571 and AG1296.Semantic proximity Read ↗

STI 571 inhibition effect on KITAsn822Lys-mediated signal transduction cascade.Semantic proximity Read ↗

Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant.Semantic proximity Read ↗

[STI571: a summary of targeted therapy].Semantic proximity Read ↗

STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications.Semantic proximity Read ↗

The C-Kit Receptor-Mediated Signal Transduction and Tumor-Related DiseasesSemantic proximity Read ↗

Identification of c-kit mutations-independent neoplastic cell proliferation of canine mast cells.Semantic proximity Read ↗

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