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Article

Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21.

Biochemical and biophysical research communications - 6 Feb 2004

Wang Chi Chiu, Kadota Mitsutaka, Nishigaki Ryuichi, Kazuki Yasuhiro, Shirayoshi Yasuaki, Rogers Michael Scott, Gojobori Takashi, Ikeo Kazuho, Oshimura Mitsuo

Abstract excerpt

Defects in neurogenesis and neuronal differentiation in the fetal brain of Down syndrome (DS) patients lead to the apparent neuropathological abnormalities and contribute to the phenotypic characters of mental retardation, and premature development of Alzheimer's disease, those being the most com...

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Source

Identifiers

PMID: 14733910
DOI: 10.1016/j.bbrc.2003.12.091

Genes

SNAPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14733910-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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