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Article

PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells.

The Journal of cell biology - 1 Apr 2004

Li Jingxia, Chen Haobin, Tang Moon-Shong, Shi Xianglin, Amin Shantu, Desai Dhimant, Costa Max, Huang Chuanshu

Abstract excerpt

5-Methylchrysene has been found to be a complete carcinogen in laboratory animals. However, the tumor promotion effects of (+/-)-anti-5-methylchrysene-1,2-diol-3,4-epoxide (5-MCDE) remain unclear. In the present work, we found that 5-MCDE induced marked activator protein-1 (AP-1) activation in Cl41 cells. 5-MCDE also induced a marked activation of phosphatidylinositol 3-kinase (PI-3K). Inhibition of PI-3K...

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Identifiers

PMID: 15067018
DOI: 10.1083/jcb.200401004
PMCID: PMC2172097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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