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Article

RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation.

Molecular and cellular biology - 1 Feb 2004

Gill Tina, Cai Ti, Aulds Jason, Wierzbicki Sara, Schmitt Mark E

Abstract excerpt

RNase mitochondrial RNA processing (RNase MRP) mutants have been shown to have an exit-from-mitosis defect that is caused by an increase in CLB2 mRNA levels, leading to increased Clb2p (B-cyclin) levels and a resulting late anaphase delay. Here we describe the molecular defect behind this delay. CLB2 mRNA normally disappears rapidly as cells complete mitosis, but the level remains high in RNase MRP mutants. This...

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Identifiers

PMID: 14729943
DOI: 10.1128/MCB.24.3.945-953.2004
PMCID: PMC321458

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