Article
A fission yeast strain expressing human CDC25A phosphatase: a tool for selectivity studies of pharmacological inhibitors of CDC25.
Current genetics - 1 May 2004
Mondesert Odile, Lemaire Matthieu, Brezak Marie-Christine, Galera-Contour Marie Odile, Prevost Grégoire, Ducommun Bernard, Bugler Béatrix
Abstract excerpt
Fission yeast is a simple eukaryotic model organism in which many aspects of cell cycle control can be explored. We examined by homologous recombination whether the human CDC25A phosphatase could substitute for the function of the fission yeast Cdc25. We first show: (a). that CDC25A efficiently replaces the endogenous Cdc25 mitotic inducer for vegetative growth and (b). that CDC25A is able to partially restore a...
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