Article
Polymorphic expression of the glutathione S-transferase P1 gene and its susceptibility to Barrett's esophagus and esophageal carcinoma.
Cancer research - 1 Feb 1999
van Lieshout E M, Roelofs H M, Dekker S, Mulder C J, Wobbes T, Jansen J B, Peters W H
Abstract excerpt
Factors determining individual susceptibility to esophageal cancer or premalignant Barrett's epithelium are still largely unclear. An imbalance between phase I drug metabolism [e.g., cytochrome P450 (CYP)] and phase II detoxification [e.g., glutathione S-transferase (GST)] may contribute to the d...
Topics
- Adenocarcinoma
- Aged
- Aged, 80 and over
- Barrett Esophagus
- Carcinoma, Squamous Cell
- Esophageal Neoplasms
- Female
- Gene Expression
- Genetic Predisposition to Disease
- Glutathione Transferase
- Humans
- Isoenzymes
- Male
- Middle Aged
- Polymorphism, Genetic