Article
Association of C609T-Inborn Polymorphism of NAD(P)H: Quinone Oxidoreductase 1 with the Risk of Bronchopulmonary Dysplasia in Preterm Neonates.
American journal of perinatology - 1 May 2016
Gavrili Stavroula, Zachaki Sophia, Daraki Aggeliki, Polycarpou Elena, Manola Kalliopi, Stavropoulou Chryssa, Sambani Constantina, Baroutis George
Abstract excerpt
UNLABELLED: Objectives In bronchopulmonary dysplasia (BPD), direct exposure to oxygen therapy can damage the pulmonary epithelium via oxidative stress. The NAD(P)H: quinone oxidoreductase 1 (NQO1) enzyme detoxifies genotoxic products of oxidative stress. The corresponding gene is subject to an inactivating single-nucleotide polymorphism (C(609)T), which reduces detoxifying ability. The aim of this study was to...
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