Article
GSTM1 and GSTT1 gene polymorphisms as major risk factors for bronchopulmonary dysplasia in a Chinese Han population.
Gene - 1 Jan 2014
Wang Xijuan, Li Wenbin, Liu Wei, Cai Baohuan, Cheng Tingting, Gao Chunfang, Mo Luxia, Yang Hui, Chang Liwen
Abstract excerpt
Bronchopulmonary dysphasia (BPD) is a complex multifactorial disease with an obvious genetic predisposition. Oxidative stress plays an important role in its pathogenesis. Glutathione S-transferases (GSTs) detoxify metabolites produced by oxidative stress within the cell and protect the cells against injury. In the present study, the hypothesis that polymorphisms in the GSTM1 and GSTT1 genes are associated with...
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