Article
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 15 Feb 2004
Fröhling Stefan, Schlenk Richard F, Stolze Ina, Bihlmayr Jörg, Benner Axel, Kreitmeier Sylvia, Tobis Karen, Döhner Hartmut, Döhner Konstanze
Abstract excerpt
PURPOSE: To assess the prognostic relevance of mutations in the CEBPA gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha) in a large prospective series of younger adults with acute myeloid leukemia (AML) and normal cytogenetics. PATIENTS AND METHODS: The entire CEBPA coding region was sequenced in diagnostic samples from 236 AML patients 16 to 60 years of age with normal cytogenetics who were...
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