Article
Pmr1, a P-type ATPase, and Pdt1, an Nramp homologue, cooperatively regulate cell morphogenesis in fission yeast: the importance of Mn2+ homeostasis.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jan 2004
Maeda Takuya, Sugiura Reiko, Kita Ayako, Saito Mariko, Deng Lu, He Yi, Yabin Lu, Fujita Yasuko, Takegawa Kaoru, Shuntoh Hisato, Kuno Takayoshi
Abstract excerpt
Schizosaccharomyces pombe pmr1+ gene is homologous to Saccharomyces cerevisiae PMR1 gene, which encodes the P-type Ca2+/Mn2+-ATPase. Addition of Mn2+, as well as Ca2+, to the medium induced pmr1+ gene expression in a calcineurin-dependent manner. The pmr1 knockout (Deltapmr1) cells exhibited hypersensitivity to EGTA. A screen for high gene dosage-suppressors of the EGTA-hypersensitive phenotype of Deltapmr1 led...
Topics
- Calcineurin
- Calcium
- Calcium-Transporting ATPases
- Cathepsin A
- Cation Transport Proteins
- Chelating Agents
- Egtazic Acid
- Manganese
- Molecular Chaperones
- Morphogenesis
- Mutation
- RNA, Messenger
- Saccharomyces cerevisiae Proteins