Article
Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant.
Leukemia - 1 Nov 1993
Macfarlane D E, O'Donnell P S
Abstract excerpt
One of the factors regulating the population size of a clone of proliferating cells is the induction of a physiological suicide mechanism known as apoptosis. We studied apoptosis in the HL-60 human promyelocytic leukemia cell line which differentiates when exposed to phorbol ester (S-cell), and in the PET-cell mutant of HL-60 which is defective in its response to phorbol ester. Exposing S-cells to...
Topics
- Apoptosis
- Calcimycin
- DNA Damage
- DNA, Neoplasm
- Drug Tolerance
- Etoposide
- Humans
- Leukemia, Promyelocytic, Acute
- Mutation
- Novobiocin
- Tetradecanoylphorbol Acetate
- Tumor Cells, Cultured