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Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Plasma Levels and Thr325Ile Genetic Polymorphism in a Cohort of Egyptian Sickle Cell Disease Patients and Impact on Disease Severity

2023-11-09

Abstract excerpt

<h4>Background: </h4> Thrombin is a critical protease modulating thrombosis as well as inflammation which are one of the main pathophysiological mechanisms in sickle vasculopathy, and its levels were reported to be high in sickle cell disease (SCD). The thrombin-thrombomodulin complex activates an inhibitor of fibrinolysis called TAFI acting by reducing plasmin affinity for its substrate hindering fibrinolysis. <...

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Literature Corpus work
9920b207-9d83-53e1-b99d-9a76742fbcfc
DOI
10.22541/au.169955794.49410413/v1
Open publication

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Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Plasma Levels and Thr325Ile Genetic Polymorphism in a Cohort of Egyptian Sickle Cell Disease Patients and Impact on Disease SeverityDOI 10.22541/au.169955794.49410413/v1
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