Article
Identification of polymorphisms in the 5'-untranslated region of the TAFI gene: relationship with plasma TAFI levels and risk of venous thrombosis.
Haematologica - 1 May 2001
Franco R F, Fagundes M G, Meijers J C, Reitsma P H, Lourenço D, Morelli V, Maffei F H, Ferrari I C, Piccinato C E, Silva W A, Zago M A
Abstract excerpt
BACKGROUND AND OBJECTIVES: Thrombin activatable fibrinolysis inhibitor (TAFI) plays an important role in hemostasis, functioning as a potent fibrinolysis inhibitor. TAFI gene variations may contribute to plasma TAFI levels and thrombotic risk. DESIGN AND METHODS: We sequenced a 2083-bp region of the 5'-regulatory region of the TAFI gene in 127 healthy subjects searching for variations, and correlated identified...
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