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Article

Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2000

Bae S S, Perry D K, Oh Y S, Choi J H, Galadari S H, Ghayur T, Ryu S H, Hannun Y A, Suh P G

Abstract excerpt

Apoptosis is a cell suicide mechanism that requires the activation of cellular death proteases for its induction. We examined whether the progress of apoptosis involves cleavage of phospholipase C-gamma1 (PLC-gamma1), which plays a pivotal role in mitogenic signaling pathway. Pretreatment of T leukemic Molt-4 cells with PLC inhibitors such as U-73122 or ET-18-OCH(3) potentiated etoposide-induced apoptosis in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10834929
DOI: 10.1096/fasebj.14.9.1083

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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