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SNX10 regulates osteoclastogenic cell fusion and osteoclast size in mice

2 Aug 2024

Abstract excerpt

Bone-resorbing osteoclasts (OCLs) are formed by differentiation and fusion of monocyte precursor cells, generating large multinucleated cells. Tightly regulated cell fusion during osteoclastogenesis leads to formation of resorption-competent OCLs, whose sizes fall within a predictable physiological range. The molecular mechanisms that regulate the onset of OCL fusion and its subsequent arrest are, however,...

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PMID: 39095084
DOI: 10.1093/jbmr/zjae125

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