Article
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.
The Journal of clinical investigation - 1 Sept 2011
Song Jason J, Hwang Inyong, Cho Kyung H, Garcia Michael A, Kim Arthur J, Wang Tiffany H, Lindstrom Tamsin M, Lee Annette T, Nishimura Toshihiko, Zhao Lei, Morser John, Nesheim Michael, Goodman Stuart B, Lee David M, Bridges S Louis, Gregersen Peter K, Leung Lawrence L, Robinson William H
Abstract excerpt
The immune and coagulation systems are both implicated in the pathogenesis of rheumatoid arthritis (RA). Plasma carboxypeptidase B (CPB), which is activated by the thrombin/thrombomodulin complex, plays a procoagulant role during fibrin clot formation. However, an antiinflammatory role for CPB is suggested by the recent observation that CPB can cleave proinflammatory mediators, such as C5a, bradykinin, and...
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