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Article

Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients.

The Journal of pathology - 1 Jan 2004

Kinoshita Kazuo, Hirota Seiichi, Isozaki Koji, Ohashi Akiko, Nishida Toshirou, Kitamura Yukihiko, Shinomura Yasuhisa, Matsuzawa Yuji

Abstract excerpt

Most sporadic gastrointestinal stromal tumours (GISTs) have somatic c-kit gene mutations that are considered to be causal. Neurofibromatosis type 1 (NF1) is caused by mutations of the NF1 gene and NF1 patients have an increased risk of developing GISTs. Since most neoplasms are considered to develop as a result of the combination of several gene mutations, these findings suggest that GISTs from NF1 patients might...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14694524
DOI: 10.1002/path.1487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients.PMID 14694524Read ↗

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