Article
c-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors.
Journal of gastroenterology and hepatology - 1 Feb 2003
Kinoshita Kazuo, Isozaki Koji, Hirota Seiichi, Nishida Toshirou, Chen Hui, Nakahara Masanori, Nagasawa Yutaka, Ohashi Akiko, Shinomura Yasuhisa, Kitamura Yukihiko, Matsuzawa Yuji
Abstract excerpt
BACKGROUND AND AIM: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the human gut. They frequently have gain-of-function mutations of the c-kit gene, which encodes a receptor, tyrosine kinase. The mutations were found at exon 11 in most cases, and either at exon 9 or at exon 13 in rare cases. Recently, we found a family with multiple GIST and a gain-of-function mutation at exon...
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