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Article

Type-Dependent Integration Frequency of Human Papillomavirus Genomes in Cervical Lesions

1 Jan 2008

Abstract excerpt

Chromosomal integration of high-risk human papillomavirus (HR-HPV) genomes is believed to represent a significant event in the pathogenesis of cervical cancer associated with progression from preneoplastic lesions to invasive carcinomas. This hypothesis is based on experimental data suggesting that integration-dependent disruption of HR-HPV E2 gene functions is important to achieve neoplastic transformation and...

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PMID: 18172324
DOI: 10.1158/0008-5472.can-07-2754

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