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Article

Integration of high‐risk human papillomavirus: a key event in cervical carcinogenesis?

15 Jun 2007

Abstract excerpt

An important occurrence in cervical carcinogenesis is deregulated expression of the high-risk human papillomavirus (HR-HPV) oncogenes E6 and E7. Several risk factors for cervical neoplastic progression are likely to contribute to viral oncogene deregulation, particularly integration of HR-HPV into the host genome. Integration represents a by-product of viral infection that is detected in almost 90% of cervical...

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PMID: 17573670
DOI: 10.1002/path.2192

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