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Article

High Fidelity of Yellow Fever Virus RNA Polymerase

23 Dec 2003

Abstract excerpt

Three consecutive plaque purifications of four chimeric yellow fever virus-dengue virus (ChimeriVax-DEN) vaccine candidates against dengue virus types 1 to 4 were performed. The genome of each candidate was sequenced by the consensus approach after plaque purification and additional passages in cell culture. Our data suggest that the nucleotide sequence error rate for SP6 RNA polymerase used in the in vitro...

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Identifiers

PMID: 14694136
DOI: 10.1128/jvi.78.2.1032-1038.2004

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