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Article

Genetic stability of a dengue vaccine based on chimeric yellow fever/dengue viruses.

Vaccine - 2 Sept 2011

Mantel N, Girerd Y, Geny C, Bernard I, Pontvianne J, Lang J, Barban V

Abstract excerpt

A tetravalent dengue vaccine based on four live, attenuated, chimeric viruses (CYD1-4), constructed by replacing the genes coding for premembrane (prM) and envelope (E) proteins of the yellow fever (YF)-17D vaccine strain with those of the four serotypes of dengue virus, is in clinical phase III evaluation. We assessed the vaccine's genetic stability by fully sequencing each vaccine virus throughout the...

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Identifiers

PMID: 21745519
DOI: 10.1016/j.vaccine.2011.06.101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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