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Article

Myosin-mediated cytoskeleton contraction and Rho GTPases regulate laminin-5 matrix assembly.

Cell motility and the cytoskeleton - 1 Feb 2004

DeHart Gregory W, Jones Jonathan C R

Abstract excerpt

Laminin-5 is a major structural element of epithelial tissue basement membranes. In the matrix of cultured epithelial cells, laminin-5 is arranged into intricate patterns. Here we tested a hypothesis that myosin II-mediated actin contraction is necessary for the proper assembly of a laminin-5 matrix by cultured SCC12 epithelial cells. To do so, the cells were treated with ML-7, a myosin II light chain kinase...

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Identifiers

PMID: 14691950
DOI: 10.1002/cm.10161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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