Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8.

doi:10.1016/j.yexcr.2003.08.010

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Article

Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8.

Experimental cell research - 1 Jan 2004

Fujiwara Hironobu, Gu Jianguo, Sekiguchi Kiyotoshi

Abstract excerpt

Blood vessel formation requires endothelial cell interactions with the extracellular matrix through cell surface receptors, and signaling events that control endothelial cell adhesion, migration, and lumen formation. Laminin-8 (alpha4beta1gamma1) is present in all basement membranes of blood vessels in fetal and adult tissues, but despite its importance in vessel formation, its role in endothelial cell adhesion...

Topics

Animals
Cell Adhesion
Cell Line, Tumor
Cell Movement
Cells, Cultured
Endothelial Cells
Fibronectins
Humans
Integrins
Laminin
Mice
Mutation
Skin
Umbilical Veins
rac GTP-Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 14720507
DOI: 10.1016/j.yexcr.2003.08.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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