Article
KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin.
Human pathology - 1 Dec 2003
Lasota Jerzy, Kopczynski Janusz, Sarlomo-Rikala Maarit, Schneider-Stock Regine, Stachura Tomasz, Kordek Radzislaw, Michal Michal, Boltze Carsten, Roessner Albert, Stachura Jerzy, Miettinen Markku
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs express KIT and show gain-of-function KIT mutations. Most of these mutations affect the KIT juxtamembrane domain, but other KIT domains are mutated at a lower frequency. In this study, frequency of GCC TAT insertion mutation (1530ins6) in KIT exon 9 (extracellular domain) and its possible...
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