Article
A whole-genome screen of a quantitative trait of age-related maculopathy in sibships from the Beaver Dam Eye Study.
American journal of human genetics - 1 Jun 2003
Schick James H, Iyengar Sudha K, Klein Barbara E, Klein Ronald, Reading Karlie, Liptak Rachel, Millard Christopher, Lee Kristine E, Tomany Sandra C, Moore Emily L, Fijal Bonnie A, Elston Robert C
Abstract excerpt
Age-related maculopathy (ARM) is a leading cause of visual impairment among the elderly in Western populations. To identify ARM-susceptibility loci, we genotyped a subset of subjects from the Beaver Dam (WI) Eye Study and performed a model-free genomewide linkage analysis for markers linked to a quantitative measure of ARM. We initially genotyped 345 autosomal markers in 325 individuals (N=263 sib pairs) from 102...
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