Article
Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family.
Human molecular genetics - 15 Dec 2003
Schultz Dennis W, Klein Michael L, Humpert Andrea J, Luzier Christina W, Persun Vesna, Schain Mitchell, Mahan Alison, Runckel Charles, Cassera Maria, Vittal Vasavi, Doyle Trudy M, Martin Tammy M, Weleber Richard G, Francis Peter J, Acott Ted S
Abstract excerpt
Age-related macular degeneration (AMD) is a common cause of severe vision loss. Identification of the genes involved in AMD will lead to a better understanding of this disease at the molecular level, which will eventually lead to early detection, prevention and treatment. Previously, we mapped the ARMD1 gene to 1q25-31 in a large family with AMD. Here, we narrow the ARMD1 locus to 14.9 Mb between LAMB2 and...
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